A new clopidogrel study was just released in JAMA that found that patient's risk of heart attack after ceasing use of clopidogrel doubled when they stopped using Plavix nine to twelve months after a stent was placed. (Bloomberg article here) The study was carried out in VA's around the country (120 or so) and wasn't funded by the drug company. It also raises the question of where the benefit of stents was coming from-from the stent itself, which has come under scrutiny as of late due to build-up of clots around the metal tubes.
For your edification and reminder, as well as a chance for me to showcase the hyperlinking capability of blogs, here are links to previous clopidogrel studies that show the possible benefit of this highly touted (and prescribed) drug, here are a couple of commentaries and dissection of the trial that set the standard of prescribing for clopidogrel prior to this study, the CURE trial. Here's one in the ol' favorite JAMA and one from respected heart hospital Cleveland Clinic's journal.
Wednesday, February 6, 2008
New clopidogrel study
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2 comments:
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